It’s a very sad day for television as House M.D. ends its record busting run after an incredible (and sometimes incredibly gross) 8 seasons. We’ve loved this medical rethinking of Sherlock Holmes more than Dr. House loves his Vicodin, but fans everywhere know how it has to end: House must develop lupus. (Just kidding, it’s never lupus!) Although we could (and did) watch the show at any hour of any day, it’s especially good sick-day viewing. No matter how bad you felt, you were always comforted by the fact that at least you weren’t bleeding out of your eyeballs or whatever horrible affliction was affecting House’s patient.
Aside from Hugh Laurie’s genius performance as the equally genius doctor, the show was bolstered by the fact that you never knew who was going to be wheeled through the ER door at Princeton Plainsboro Teaching Hospital. Every episode brought the potential for an inspired cameo, and the series had many over its 177 episodes. So to say goodbye to the magnificent drama, we’ve assembled a list of the 30 most surprising guest stars to ever appear on House M.D. Join us in saluting the great Mr. Laurie as he hangs up his cane for the very last time and goes to the great detox in the sky.